1981 Wimbledon Championships – Women's singles

Women's singles
1981 Wimbledon Championships
Champion Chris Evert Lloyd
Runner-up Hana Mandlíková
Score6–2, 6–2
Draw96 (8 Q / 6 WC )
Seeds16

Chris Evert Lloyd defeated Hana Mandlíková in the final, 6–2, 6–2 to win the ladies' singles tennis title at the 1981 Wimbledon Championships. It was her third Wimbledon singles title and her twelfth major singles title, surpassing Margaret Court's Open Era record. Evert did not lose a set during the tournament.

Evonne Goolagong Cawley was the reigning champion, but did not compete due to pregnancy.