1980–81 Cuban National Series
| 1980–81 Cuban National Series Serie Nacional de Béisbol 1980–81 | |
|---|---|
| League | Cuban National Series |
| Sport | Baseball |
| Number of games | 51 |
| Number of teams | 18 |
| Regular season | |
| Champion | Vegueros (36–15) |
The 20th Cuban National Series saw Vegueros, from Pinar del Río Province, win its second title, with Villa Clara and Citricultores each finishing three games behind. The 18 teams of the league, each with a 51-game schedule, remained unchanged from the prior season.