1959 U.S. National Championships – Women's singles
| Women's singles | |
|---|---|
| 1959 U.S. National Championships | |
| Champion | Maria Bueno |
| Runner-up | Christine Truman |
| Score | 6–1, 6–4 |
| Draw | 64 |
| Seeds | 8 |
First-seeded Maria Bueno defeated Christine Truman 6–1, 6–4 in the final to win the women's singles tennis title at the 1959 U.S. National Championships.
This was notably the first grand slam that former world number 1 and 12 time grand slam champion Billie Jean King competed in.