1945 U.S. National Championships – Women's singles
| Women's singles | |
|---|---|
| 1945 U.S. National Championships | |
| Champion | Sarah Palfrey Cooke |
| Runner-up | Pauline Betz |
| Score | 3–6, 8–6, 6–4 |
| Draw | 32 |
| Seeds | 8 |
Second-seeded Sarah Palfrey Cooke defeated first-seeded Pauline Betz 3–6, 8–6, 6–4 in the final to win the women's singles tennis title at the 1945 U.S. National Championships.