1943 U.S. National Championships – Women's singles
| Women's singles | |
|---|---|
| 1943 U.S. National Championships | |
| Champion | Pauline Betz |
| Runner-up | Louise Brough |
| Score | 6–3, 5–7, 6–3 |
| Draw | 32 |
| Seeds | 8 |
First-seeded and reigning champion Pauline Betz defeated second-seeded Louise Brough 6–3, 5–7, 6–3 in the final to win the women's singles tennis title at the 1943 U.S. National Championships. The tournament was played on outdoor grass courts and held from September 1 through September 4, 1943 at the West Side Tennis Club in Forest Hills, Queens, New York.
The draw consisted of 32 players of which eight were seeded.